![]() Decreased PCO 2 causes Hb-O 2 affinity to increase (decreased P 50), and increased PCO 2 causes Hb-O 2 affinity to decrease (increased P 50). ![]() The Bohr effect describes changes in P 50 with changes in blood PCO 2 and pH. Therefore,, in g/dL of blood, depends on both of these factors: ![]() Mean corpuscular Hb concentration ( MCHC) quantifies in red blood cells and hematocrit (Hct) quantifies the percentage of blood volume that is red blood cells. However, changes in Hb concentration will change the maximum height of the concentration curve, according to the relationship between O 2cap and as described previously. The maximum height of the saturation curve cannot change by definition the maximum is always 100% when O 2 is bound to all available Hb sites. The O 2-equilibrium curve can be physiologically modulated in three ways: (a) the vertical height of the concentration curve (but not the saturation curve) can change, indicating a change in O 2cap, (b) the horizontal position of saturation and concentration curves can change, indicating a change in Hb-O 2 affinity, and (c) the shape of saturation and concentration curves can change, indicating a change in the chemical reaction between O 2 and Hb. = O 2 consumption per unit timeĪ = Ventilation of the alveoli per unit time PaO 2 = Partial pressure of O 2 in arterial bloodį CO 2 = Fraction of CO 2 in dry mixed, expired gas PAO 2 = Partial pressure of O 2 in alveolar gas Respiratory exchange ratio (dimensionless) Gas pressure or partial pressure (cm H 2O or mm Hg) TABLE 43.1 SYMBOLS IN RESPIRATORY PHYSIOLOGYĬoncentration or content (mL/dL or mmol/L)ĭiffusing capacity įractional concentration in dry gas (dimensionless)
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